|
KMID : 0363320220430040529
|
|
Journal of Korean Oriental Internal Medicine
2022 Volume.43 No. 4 p.529 ~ p.541
|
|
|
Effect of Extract of Acanthopanax Senticosus Fruit on Breast Cancer Cells
|
|
Hwang Jong-Hyun
Hwang Gwi-Seo
Jeon Chan-Yong
Kang Ki-Sung
Kim Seung-Man
|
|
|
Abstract
|
|
|
Objectives: Acanthopanax senticosus is a tree used in traditional medicine for various diseases. In this study, we investigated the anti-cancer effects of a water extract of Acanthopanax senticocus fruit (ASF) on 2 human breast cancer cell lines (MCF-7 and MDA-MB-231).
Methods: The MTT assay was used to assess cell proliferation. The expression of apoptosis-related genes was assessed by quantitative real-time PCR.
Results: ASF treatment caused a dose-dependent inhibition of cell growth in both estrogen-independent MDA-MB-231 and estrogen-dependent MCF-7 breast cancer cells. ASF decreased mRNA expression of the apoptotic suppressor gene Bcl-xL, and increased mRNA expression of proapoptotic genes. ASF increased the mRNA expression of p21 and RIP-1 in both cell types. ASF decreased the mRNA expression of survivin in the MCF-7 cell line.
Conclusions: ASF exhibits anti-cancer activity involving apoptotic cell death.
|
|
|
KEYWORD
|
|
|
Acanthopanax senticosus, breast cancer, MCF-7, MDA-MB-231
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|